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Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid

Year: 2025

Type: article

Abstract: , etc., also decreased glyceryl palmitate, and eicosapentaenoic acid. Bioinformatics analysis indicated that specific gut microbiota and metabolites were related to behavioral changes. Notably, EPA supplementation alleviated these neurobehavioral deficits. These findings support a role for the gut microbiota and its metabolites in sevoflurane-induced neurodevelopmental injury, potentially mediated via the microbiota-gut-brain axis. Supplementation with key metabolites may provide a therapeutic strategy for mitigating such injuries.

Source: iScience

DOI: 10.1016/j.isci.2025.113657