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Ruptured Gastrointestinal Stromal Tumor in a 12-Year-Old Child: A Case Report

Year: 2025

Type: article

Abstract: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms, especially in pediatric patients, often presenting with distinct clinical and molecular characteristics. This case report describes a 12-year-old girl with a large gastric GIST complicated by tumor rupture and hemoperitoneum. Initial treatment with imatinib was followed by emergent surgical intervention due to tumor bleeding. Histopathology confirmed an epithelioid-type GIST, necessitating continued imatinib therapy. Pediatric GISTs demonstrate an indolent but unpredictable course, requiring a multidisciplinary approach. Despite their aggressive nature, pediatric cases show better survival outcomes than adults. This case underscores the importance of timely intervention, individualized therapy, and long-term follow-up to improve prognosis in children with GISTs.

Source: Cureus

DOI: 10.7759/cureus.93353

Authors: Ashwin Rajkumar J, Prakash Agarwal, Madhu R, Jegadeesh Sundaram, Latha M Sneha

Institutions: Sri Ramachandra Institute of Higher Education and Research, Apollo Hospitals, Apollo Hospitals

Language: English

Topic: Gastrointestinal Tumor Research and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414569690