Small Cell Neuroendocrine Carcinoma of the Gallbladder: Natural History and Therapeutic Challenges
Year: 2025
Type: article
Study design: Case Report
Abstract: Small cell neuroendocrine carcinoma (SNEC) of the gallbladder is an extremely rare and aggressive primary gallbladder malignancy with poor prognosis. A 65-year-old woman presented with constipation followed by jaundice and right upper quadrant pain one month later. Imaging revealed a porta hepatis mass with hepatic and duodenal involvement. Fine needle aspiration confirmed metastatic small cell carcinoma positive for synaptophysin, chromogranin, and CDX2 with Ki-67 >70%. Despite planned platinum-etoposide chemotherapy, rapid disease progression with inferior vena cava invasion precluded treatment. The patient died 13 weeks after symptom onset. This case demonstrates the aggressive natural history of gallbladder SNEC. Early tissue diagnosis and prompt platinum-etoposide chemotherapy initiation while performance status permits remain critical for meaningful survival benefit.
Source: Cureus
DOI: 10.7759/cureus.93358
Authors: Niket Shah, Alicia Edwards, Jason P Law, Nasreen Al-Qadi, Mukta Sharma
Institution: Michigan State University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414569783