Advances in Cancer Therapy: A Comprehensive Review of Fourth Generation EGFR Inhibitors and their Role in Defeating Drug Resistance
Year: 2025
Type: article
Abstract: The treatment of cancer has changed significantly as a result of the development of targeted medications, particularly inhibitors of the receptor for epidermal growth factor (EGFR), which is crucial for the development and survival of cancer. Cancers of the colorectal, head and neck, and non-small cell lung varieties often include EGFR overexpression and mutations. The safety records, clinical effectiveness, and action mechanisms of 4 thgeneration EGFR inhibitors are the primary foci of this review. The T790M mutation is one example of a resistance mechanism that these newer, more potent inhibitors aim to counteract. In order to give patients with EGFR-mutant cancers that are resistant to earlier treatments new hope, the review outlines recent clinical developments and examines the potential applications of 4 th -generation EGFR inhibitors in cancer treatment.
Authors: Asha Hole, Shashikant Bhandari
Institution: Savitribai Phule Pune University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4414570839
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