Pharmacodynamic insights to support pneumonia treatment in a patient co-infected with two carbapenem-resistant bacteria
Year: 2025
Type: article
Study design: Case Report
Abstract: carbapenemase while the mechanism of carbapenem resistance in the P. aeruginosa was likely due to OprD loss combined with extended-spectrum β-lactamase expression. The putative mechanism of cefiderocol resistance in the P. stuartii isolate was identified as a premature stop codon in the cirA-like gene combined with the presence of β-lactamases. The patient's carbapenem-resistant coinfection was successfully treated with agents that were validated in real time using personalized TKAs. TKAs may be useful to optimize combination antibiotic therapy for patients infected with extensively resistant bacteria.
Authors: Brooke N. Curry, Nidhi Singh, Alan E. Gross, Jackson V. Watkins, Egon A. Ozer, Arunkumar Karunanidhi, Kayley Sherwood, Osayamen Obanor, Nahed Ismail, Alan R. Hauser, Zackery P. Bulman
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,280
Award: G2109399541
OpenAlex ID: W4414574024