Cigarette smoking induces NLRP3 inflammasome activation in patients with atrial fibrillation
Year: 2025
Type: article
Study design: Observational Study
Abstract: This study demonstrates that atrial fibrillation patients who have had a history of cigarette smoking within the past year exhibit increased inflammation amplified by NLRP3 inflammasome activation and heightened endoplasmic reticulum (ER) stress. Our findings suggest that ER stress acts as an upstream activator of the NLRP3 inflammasome, presenting a potential therapeutic target to mitigate the excessive inflammation observed in patients with AF with smoking exposure.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Funders: U.S. Department of Veterans Affairs, American Heart Association, Tobacco-Related Disease Research Program, Health Resources in Action, National Institutes of Health, University of California, Davis, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences, NHLBI Division of Intramural Research
Awards: G1185946596, G1351866155, G1508866, G2536180224, G3611106499, G4487539205, G4627689340, G5257279998, G5496526517, Psychosocial stRessors and Exposomics on CV health In underServed multiEthnic populations in Northern CA (PRECISE), G5959061814, G6641374964, Mechanistic links between inflammatory cascades and psychosocial stressors in CVD, Mechanisms Underpinning Afterload-Induced Atrial Fibrillation, G7448161986, Translational Study of Cardiac Dysfunction, G8920997761, Training Program in Basic and Translational Cardiovascular Science, Functional interactions of cardiac ion channels, Initiative for Maximizing Student Development at the University of California, Davis., G900591525, G954386746, G988438089
OpenAlex ID: W4414575472