Work

Leukocytosis, Monocytosis, and Eosinophilia in Systemic Mastocytosis: Analysis of Phenotype, Genetics and Prognosis in 596 Patients From the GREM Registry

Year: 2025

Type: article

Abstract: BACKGROUND: Leukocytosis, monocytosis, and eosinophilia (L/M/E) are recurrent findings in systemic mastocytosis (SM). OBJECTIVE: To investigate the prevalence of L/M/E in SM and assess their association with clinical phenotype, mutational profile, and overall survival (OS) in advanced SM (AdvSM). METHODS: Within the German Registry on Disorders of Eosinophilia and Mast Cells, 596 patients with SM (91% KIT D816V positive; 270 AdvSM, 326 non-AdvSM) were analyzed for L/M/E. RESULTS: /L for eosinophilia (1.7 vs 5.0 years, P < .001). Monocytosis and/or eosinophilia defined a 3-tiered risk model (median OS: 1.60 vs 3.04 vs 6.94 years, P < .001). CONCLUSIONS: Elevated counts of L/M/E are indicative of AdvSM and within AdvSM associated with additional somatic mutations, a subtype of SM-AHN and poor prognosis.

Source: The Journal of Allergy and Clinical Immunology In Practice

DOI: 10.1016/j.jaip.2025.09.018