Work

Conventional tobacco and electronic cigarettes differentially affect cardiovascular health in male and female mice

Year: 2025

Type: article

Abstract: Effects of electronic cigarettes (E-cigs) compared with tobacco cigarettes (T-cigs) in the Western population are largely undetermined. Here, we assessed chronic, intermittent exposures to either E-cigs or T-cigs on cardiovascular parameters in hyperlipidemic mice with similar nicotine levels. Our findings suggest that both E-cigs and T-cigs imposed adverse effects on cardiac function, heart chamber size, and atherosclerotic lesions in diet and sex-dependent manners, suggesting that electronic cigarettes are not a safer alternative to conventional cigarettes.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00492.2025

Authors: Candice J. Lao, Maria C. Jordan, Juan Carlos Rivera, Yin Tintut, Karla Luna, William Ramirez-Trillo, Trent Yamamoto, Bilal Pandit, Cherie Huang, Angela Li, Sophia Lewis Wang, Thalia Nguyen, Valentina Castro, Ayushi Kothari, Victoria C. Chen, Xuesi M. Shao, Theodore C. Friedman, Kenneth P. Roos

Institutions: University of California, Los Angeles, Charles R. Drew University of Medicine and Science

Language: English

Topic: Smoking Behavior and Cessation

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Congressionally Directed Medical Research Programs, NHLBI Division of Intramural Research

Awards: Serotonin receptor contribution to inflammation-induced calcific aortic valve disease, G2159413366, G2823939670, G397533675, G4287227849, G4336402479, G5089131619, G5295862686, G7788729828, G8963879111

OpenAlex ID: W4414584770

FWCI: 1.593

Cites: 35

Cited by: 3

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