Work

Correlation Between Lactate, Albumin, Lactate/Albumin Ratio, and SOFA Score in Sepsis Patients

Year: 2025

Type: article

Abstract: Background & Objective: Sepsis is a condition with various body responses and often results in death from infection.Serum lactate levels, elevated during hypoxia, stress, and critical illness, can serve as a sensitive yet non-specific indicator of metabolic stress.Hypoalbuminemia may be present in sepsis and exacerbate its severity.Researchers propose the lactate/albumin ratio (LAR) as a marker associated with multi-organ failure, and the SOFA score assesses mortality in critically ill patients.This study aims to investigate the correlation between lactate, albumin, LAR, and the SOFA score in septic patients. Materials & Methods:Thirty-five patients with sepsis were enrolled in this study.The LAR assessment and SOFA score were manually calculated; lactate and albumin levels were determined using a clinical chemistry analyzer.The Spearman test was employed to analyze the data, with a significance level of p < 0.05. Results:The median levels of lactate, albumin, and LAR were 5.50 (1.90-10.40)mmol/L, 2.40 (0.90-3.70) g/dL, and 2.29 (0.53-7.46), respectively.The results of the Spearman correlation test between albumin levels and the SOFA score showed no correlation (p = 0.643 and r = -0.081).Lactate, LAR, and the SOFA score showed a significant correlation (p = 0.002 and r = 0.498, p = 0.001 and r = 0.538).Conclusion: There is a potential relationship between lactate, and LAR parameters and organ dysfunction severity.

Source: Journal of Advances in Medical and Biomedical Research

DOI: 10.30699/jambr.33.158.218

Authors: Vera Oktaria Putri, Ardhea Jaludamascena, Dwi Retnoningrum

Institutions: Diponegoro University, Dr. Kariadi Hospital

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414584832