Cytotoxicity, Acute and Subacute Toxicity Evaluation of Hydroethanolic Extract of Dialium Guineense Willd Fruit Pulp
Year: 2025
Type: article
Abstract: Objective: This study aims to evaluate the acute and subacute toxicity, as well as the cytotoxicity of the hydroethanolic extract of D. guineense willd fruit pulp. Methodology: Three different tests were performed. The cytotoxicity test was performed using Artemia salina larvae. The acute toxicity test was conducted by single oral administration of Dialium guineense at 5000 mg/kg. When subacute toxicity tests were performed by repeated oral administration of Dialium guineense at 250, 500, and 1000 mg/kg/day for 28 days. Results: The fruit pulp of Dialium guineense presented a CL50 equal to 1.40 mg/mL and an LD50 greater than 5000 mg/kg. This pulp at the dose of 1000 mg/kg significantly reduced blood glucose as well as the overall white blood cell counts, particularly neutrophils and eosinophil polymorphonuclear cells, at low doses after 28 days of treatment. Conclusion: The hydroethanolic extract of the Dialium guineense willd fruit pulp does not show signs of cytotoxicity, major acute or subacute toxicity.
Source: Biomedical Sciences
Institutions: University of Lomé, University of Kara
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4414585093