Factors Predicting Failure of Medical Treatment for Fibroadenosis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Fibroadenosis, also known as fibrocystic breast disease, is a common benign breast condition affecting women of reproductive age. While medical treatment—often involving hormonal modulation, analgesics, and lifestyle modifications—can alleviate symptoms, a subset of patients fail to achieve adequate relief, leading to persistent symptoms or recurrence. Identifying factors that predict failure of medical therapy is critical for optimizing management strategies, reducing unnecessary treatment delays, and guiding early surgical intervention when indicated. So, we aimed to determine the factors predicting failure of medical treatment for fibroadenosis. Methods: This cross-sectional study was conducted in the General Surgery Department of Zagazig University Hospital, Zagazig on patients who were presented with breast pain primarily attributed to fibroadenosis at the General Surgery Department of Zagazig University Hospital during the study period. Results: Regarding univariate Associations, older age, diabetes, hypertension, positive family history, infertility, cyclical tenderness, breast heaviness, and palpable lumps were significantly linked to treatment failure (p < 0.05). Regarding multivariate Analysis, history of infertility (OR ≈ 43, p = 0.019) and cyclical breast tenderness (OR ≈ 43, p = 0.019) emerged as independent predictors of medical management failure. Other variables lost significance after adjustment. Conclusion: Most fibroadenosis patients responded positively to a regimen of evening primrose oil, NSAIDs, and cabergoline, while infertility history and cyclical breast tenderness were identified as significant independent predictors of treatment failure.
Authors: Ahmed Magdy Ibraheem Tantawy, Mansour Mohamed Morsy Omar, Ramadan Mahmoud Mohamed Ali, Joseph Rizk Israel
Institution: Zagazig University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414585392
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