Work

Dynamic regulation of cell death signaling

Year: 2025

Type: review

Abstract: There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from common triggers activating interconnected signaling networks that diverge at key decision points during cell death initiation, progression, and execution. Despite the death of each cell being a unique biomolecular event, shared features allow us to categorize the process depending on the pathways activated and their outcomes. Here we outline core concepts about the dynamic interplay between cell death pathways, focusing on apoptosis, necroptosis, pyroptosis, and ferroptosis. We highlight unresolved decision points, including the dynamics of pore formation and the points of no return. We also discuss conceptual commonalities across systems and outline key recent developments that refine our understanding of the dynamic regulation of cell death.

Source: Current Opinion in Cell Biology

DOI: 10.1016/j.ceb.2025.102583

Authors: Asma Majoul, Ana J. Garcia-Saez

Institutions: University of Cologne, Max Planck Institute of Biophysics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,390

Funder: Deutsche Forschungsgemeinschaft