Work

Ten previously undescribed norsesquiterpenoids from the fungus Marasmiellus candidus and their anti-inflammatory activities

Year: 2025

Type: article

Abstract: In this study, ten undescribed norsesquiterpenoids, named marasmiellactones R−U (1−4) and marasmielolic acids A−F (5−10), were isolated from the cultures of the fungus Marasmiellus candidus. Their planar structures were characterised using comprehensive spectroscopic techniques, including 1D/2D NMR and HRESIMS, while the absolute configurations were determined by comparing experimental and calculated ECD spectra. In addition, the anti-inflammatory activities of isolated compounds were evaluated by using an LPS-induce RAW 264.7 cell model. Compounds 1−4 demonstrated good anti-inflammatory activity, with IC50 values of 18.2, 16.7, 22.1, and 15.5 μmol/L, respectively.

Source: Mycology&#58 An International Journal on Fungal Biology

DOI: 10.1080/21501203.2025.2551650

Authors: Lan Yao, Shiyu Li, Jinxiu Zhang, Zhuang Li, Jianhua Lv

Institutions: Hebei Academy of Sciences, Hebei Normal University, Jilin Agricultural University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,165