Year: 2025
Type: article
Abstract: With the expansion of the ageing population, cognitive decline has become an increasingly pressing challenge. 1 As life expectancy increases, its socioeconomic burden is also increasing, highlighting the urgent need for effective interventions. Numerous studies suggest that specific dietary patterns and nutritional interventions may help mitigate cognitive decline associated with ageing.2 Among these, caloric restriction (CR), which aims to extend lifespan through reduced calorie intake, has gained significant research interest in recent years.3 However, the optimal CR regimen remains difficult to define due to the risk of malnutrition and other potential adverse effects. Moreover, maintaining long-term adherence to CR can be difficult for most individuals. Consequently, the use of caloric restriction mimetics (CRMs), compounds that replicate the physiological benefits of CR without requiring stringent dietary modifications, has emerged as a promising and potentially practical alternative. Among these, increasing evidence suggests that CR and intermittent fasting may elevate endogenous levels of spermidine (SPD), a polyamine compound now being investigated as a natural CRM candidate.4
Source: General Psychiatry
Institutions: Weifang Medical University, Chengdu University of Traditional Chinese Medicine, Changchun University of Chinese Medicine, National University of Singapore, National University Health System, University of Health and Rehabilitation Sciences, Guangzhou First People's Hospital, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
Awards: G1252815362, G1969846390
OpenAlex ID: W4414592222