Year: 2025
Type: article
Abstract: EMSY is critical in the progression of ovarian cancer; nevertheless, its impact on tumor metabolism is not widely known. This study showed ovarian cancer cells overexpressing EMSY produce more lactate and have upregulated LDHA expression; the promoting effect of EMSY on the malignant phenotype of these cells is eliminated when LDHA expression is knocked down or glycolysis is inhibited in ovarian cancer cells. Mechanistic studies revealed that EMSY interacts with β-catenin, and the knockdown of EMSY inhibits the transcriptional activation of LDHA by β-catenin. In summary, this study identifies EMSY's metabolic regulatory role in ovarian cancer cells and offers treatment of ovarian cancer with a new therapeutic target.
Authors: Shaosheng Wang, Na Xie, Ping Zha, Yingming Li, Minghui Wei, Ji Bai, Xiaohong Zhao
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,190
Award: EMSY在卵巢癌转移中的功能研究
OpenAlex ID: W4414592255