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The role of gut dysbiosis in the pathogenesis of neurodegenerative diseases

Year: 2025
Type: article
Abstract: Stevn mikrobiom hraje zsadn roli v regulaci centrlnho nervovho systmu prostednictvm osy stevo-mozek, piem zejmna v posledn dekd se objevuj nov zjitn, implikujc klovou roli jeho nerovnovhy - dysbizy - v patogenezi ady neurodegenerativnch onemocnn, zejmna Alzheimerovy choroby, Parkinsonovy choroby a amyotrofick laterln sklerzy. Zkladn mechanismy zahrnuj zvenou stevn permeabilitu, neuroinflamaci, metabolity mikrobioty a naruen neurotransmiterov signalizace. Experimentln studie naznauj, e modulace stevnho mikrobiomu, napklad prostednictvm fekln mikrobiln transplantace, me ovlivnit klinick prbh tchto nemoc. K objasnn kauzality a potencilu terapeutickch intervenc je nutn dal a dkladnj vzkum.
Language: English
Open Access status: bronze
OpenAlex ID: W4414595307
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Cites: 33
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