Work

Comparative study on the predictive value of TyG, TyG-BMI, and TG/HDL-C for progression-free survival in patients with locally advanced nasopharyngeal carcinoma

Year: 2025

Type: article

Abstract: Background: This study aimed to explore the relationship between the triglyceride glucose (TyG) index, triglyceride glucose-body mass index (TyG-BMI), and triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) of locally advanced nasopharyngeal carcinoma (LA-NPC) and progression-free survival (PFS) to investigate their potential as prognostic indicators. Methods: This research involved a retrospective analysis of data pertaining to patients with LA-NPC from the Guangxi Medical University Cancer Hospital. The analysis categorized patients into a progression group and a control group according to their disease control status. The correlation of three indicators with PFS was established utilizing the Cox proportional hazards model, Kaplan-Meier (K-M) analysis, and restricted cubic spline (RCS) analysis. Three predictive models were developed based on the three indicators, and their predictive ability was assessed. Results: TyG, TyG-BMI, and TG/HDL-C are independent predictors of PFS in LA-NPC patients, and all exhibit a non-linear relationship. Patients in the high TyG, TyG-BMI, and TG/HDL-C groups have significantly lower PFS compared to those in the low groups, and this effect persists after adjusting for confounding factors. A multivariate analysis confirmed that lactate dehydrogenase (LDH) and EBV_DNA are also independent prognostic factors for PFS. The models that utilize these indicators outperform traditional tumor node metastasis (TNM) staging, with the TyG-based model demonstrating the strongest predictive ability for PFS. Conclusion: TyG, TyG-BMI, and TG/HDL-C are potential prognostic biomarkers for the evaluation of PFS in individuals diagnosed with LA-NPC. Our research underscores the potential of these three indices to be utilized to enhance prognostic assessment and customize treatment strategies in the management of LA-NPC.

Source: Frontiers in Nutrition

DOI: 10.3389/fnut.2025.1657646

Authors: Zhehao Xiao, Zhuowei Liang, Weiling Chen, Hejing Huang, Song Qu

Institutions: Guangxi Medical University, Tumor Hospital of Guangxi Medical University

Language: English

Topic: Head and Neck Cancer Studies

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801