Work

Superselectivity in Weakly Multivalent Targeting of Supported Lipid Bilayers

Year: 2025

Type: article

Abstract: Understanding how multivalency contributes to targeting dynamic lipid membranes is challenging. We show superselectivity in the multiple weak interactions formed between vesicles displaying nickel(II)-complexing nitrilotriacetic acid (NTA(Ni)) and histidine (His)-displaying supported lipid bilayers (SLBs). The lateral mobility of receptors on the SLBs led to receptor recruitment inside the contact area between vesicle and SLB and depletion outside of the contact area in the case of low receptor density at the SLB and high ligand density in the targeting vesicles.

Source: CCS Chemistry

DOI: 10.31635/ccschem.025.202506418

Authors: Mark L. Verheijden, Jurriaan Huskens, Pascal Jonkheijm

Institution: University of Twente

Language: English

Topic: Lipid Membrane Structure and Behavior

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Award: G5225129140