Year: 2025
Type: article
Abstract: Imidazole has become an important synthon in the development of new drugs.The unique structural feature of the imidazole (1, 3-diazole) ring with a desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with various enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities.The derivatives of 1, 3-diazole show different biological activities such as antibacterial, antimycobacterial, anti-inflammatory, antitumor, antidiabetic, anti-allergic, antipyretic, antiviral, antioxidant, anti-amoebic, antihelmintic, antifungal, and ulcerogenic activities, etc.The present study, 2,4,5-triphenyl imidazole derivatives were synthesized using benzil, substituted aldehydes, ammonium acetate, and triethylammonium acetate.The synthesized compounds were characterized using mass spectroscopy and evaluated for antibacterial activity.The antibacterial report shows that compounds 1a and 1b show a maximum zone of inhibition against Bacillus subtilis.
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4414602329
FWCI:
Cites:
Cited by:
Related to: