Work

Association between single nucleotide polymorphisms in vitamin D related and parathyroid hormone genes with nonsyndromic oral cleft

Year: 2025

Type: article

Abstract: OBJECTIVE: Nonsyndromic oral clefts (NSOC) result from disruptions in the development of the primary and secondary palate and are categorized into cleft lip (CL), cleft lip and palate (CLP) and cleft palate (CP). NSOC is a condition with complex genetically heterogeneous backgrounds for that several genes might be involved. Thus, this study investigated whether functional single nucleotide polymorphisms (SNPs) in genes that potentially influence the vitamin D levels and parathyroid hormone (PTH) levels are associated with NSOC. MATERIALS AND METHODS: test at a significance level of p < 0.005 (after Bonferroni correction). RESULTS: The sample consisted of 274 individuals: 154 NSOC individuals and 120 controls. A total of 43 (27.9%) had CL, 91 (59.1%) had CLP and 20 (13.0%) had CP. After Bonferroni correction, none of the SNPs were associated with NSOC (p > 0.005). CONCLUSION: None of the studied SNPs in vitamin D related and parathyroid hormone genes were associated with NSOC.

Source: Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie

DOI: 10.1007/s00056-025-00614-w