Year: 2025
Type: article
Study design: Observational Study
Abstract: Hyperthyroidism complicated by liver failure is associated with high mortality, and the optimal treatment strategy remains unclear. We aimed to compare the clinical characteristics of patients who received different treatments for hyperthyroidism and liver failure. This retrospective cohort study included 137 patients diagnosed with hyperthyroidism and Liver failure between January 2013 and December 2022. The patients were treated with methimazole (MMI) plus artificial liver support system (ALSS), radioactive iodine ( 131 I) plus ALSS, or MMI alone for 24 weeks. Liver and thyroid function were monitored to determine treatment efficacy and potential complications. After propensity score matching, no significant differences in treatment efficacy were observed between MMI plus ALSS and MMI alone at discharge ( P = 0.425), 12 weeks ( P = 0.104), or 24 weeks ( P = 0.104). There were also no significant differences in treatment efficacy between 131 I plus ALSS and MMI alone. However, hospital stays were shorter in the MMI and 131 I plus ALSS groups than in the MMI alone group ( P = 0.014 and P = 0.010, respectively). The incidence of adverse events did not differ significantly between the groups. Our results suggest that 131 I plus ALSS, MMI plus ALSS or MMI are effective in treating hyperthyroidism and liver failure, and that the addition of ALSS reduces recovery times. Therefore, clinicians can select any of these treatment options based on specific patient characteristics.
Source: BMC Gastroenterology
Institution: Third Affiliated Hospital of Sun Yat-sen University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
OpenAlex ID: W4414608510