Work

Identification and validation of centrosome-related features predicting prognosis in hepatocellular carcinoma

Year: 2025

Type: article

Abstract: Hepatocellular carcinoma (HCC) is commonly linked with centrosome abnormalities that contribute to chromosomal instability and tumor progression. Four prognostic centrosome-related genes (CRGs): DYNLL1, CEP85, C10orf90, and CETN1 were utilized to develop a risk model for HCC. The model demonstrated strong prognostic reliability. Both risk score and risk group served as independent prognostic predictors for HCC. Further analyses revealed that the low-risk group was associated with metabolism and detoxification pathways and exhibited a lower abundance of M2 macrophages. Additionally, high expression levels of DYNLL1 and CETN1 were significantly correlated with poorer prognosis, with upregulation of DYNLL1 confirmed in HCC patients.

Source: Computer Methods in Biomechanics & Biomedical Engineering

DOI: 10.1080/10255842.2025.2566280

Authors: Qingqing Wang, Yifan Lu, Songhai Chen, Xuanzeng Pei, Jie Zhang

Institutions: Jiaxing University, First Hospital of Jiaxing

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4414609132