Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort
Year: 2025
Type: article
Study design: Observational Study
Abstract: Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.
Authors: Valentina Pucinischi, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Lorenzo Norsa, Giovanni Di Nardo, Maria Elisabetta Baldassarre, Maria Chiara Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Federica Malerba, Fernanda Cristofori, Luca Elli, Alessio Fasano, Francesco Valitutti, Maureen M. Leonard, CDGEMM Team
Institutions: Sapienza University of Rome, Massachusetts General Hospital, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Ospedale Pediatrico Giovanni XXIII, Ospedale dei Bambini Vittore Buzzi, University of Bari Aldo Moro, Bambino Gesù Children's Hospital, Ospedale Papa Giovanni XXIII, Istituto Giannina Gaslini, University of Salerno, European Biomedical Research Institute of Salerno, University of Perugia
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: The Celiac Disease Genomic, Environmental, Microbiome, and Metabolomic (CD-GEMM) Prospective Cohort Study, The Celiac Disease Genome, Environment, Microbiome, and Metabolome (CD-GEMM) prospective cohort study, Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis, Boston Area Nutrition Obesity Research Center (NORC)
OpenAlex ID: W4414609586