In Silico and RP HPLC Studies of Biologically Active 1,3,4-Thiadiazol-2-yl)-benzene-1,3-diols
Year: 2025
Type: article
Abstract: Biologically active compounds from the 1,3,4-thiadiazol-2-yl)-benzene-1,3-diols group described earlier have been studied. Various approaches were used to determine their lipophilicity and predict pharmacokinetic properties. The lipophilicity parameters log kw were determined using isocratic column chromatography and various stationary phases. Based on the standard curve and retention measurements by using an octadecyl column, the log D7.4 distribution coefficient was determined. A weak correlation was found between the experimentally determined log kw parameters and the in silico calculated log P descriptors. It was shown that the compounds partially exist in an ionized anionic form at physiological pH. The determined log D7.4 parameter indicates that most of them have lipophilic character at the level recommended for potential drugs.
Source: Molecules
Authors: Marek Studziński, Katarzyna Barańska, Beata Paw, Bogusław Senczyna, Tadeusz Paszko, Joanna Matysiak
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W4414610357