Impact of material characteristics on nanoparticle penetration and retention in thrombi: implications for thrombolysis
Year: 2025
Type: article
Abstract: gold and silver) and metal oxide nanomaterials have been developed for thrombolysis and molecular imaging of thrombi. Based on this, we employed gold and silver nanoparticles in our study. Nanoparticles ranging from 10 to 200 nm in size, with both positive and negative surface charges, and in spherical and rod-shaped forms, were evaluated using two-photon microscopy, loop-based diffusion, and both static and dynamic microchannel thrombus models. It was found that the physicochemical characteristics of nanoparticles strongly influence their ability to penetrate and accumulate within the thrombus. In particular, the larger the particle size, the lower the penetration and the higher the retention. Negative surface charge and silver materials favour penetration of the particles compared to positively charged or gold particles, respectively. Particle shape is also an influence factor, where a rod shape reduces penetration and increases retention. These findings provide valuable insights for designing future diagnostic and therapeutic nanoparticles.
Source: Biomaterials Science
DOI: 10.1039/d5bm01192b
Authors: Xiangxun Chen, Haotian Cha, Shehzahdi S. Moonshi, Nam-Trung Nguyen, Hang Thu Ta
Institution: Griffith University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
Awards: Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis, Materials to cross gastrointestinal barrier and escape liver metabolism, Innovative Reversible Hemostatic Nanomaterial for Emergency Treatment of Internal Bleeding, G7835754168
OpenAlex ID: W4414610859