Work

Construction of α-quinonyl-α-hydroxy/amino acid esters through the redox chain reaction

Year: 2025

Type: article

Abstract: oxidation of corresponding tartrates to glyoxylates by PIDA. Moreover, aminoalkylation of quinones was achieved by the multicomponent reaction of quinones, glyoxylates and amides, affording a series of α-quinonyl-α-aminoacetyl esters in up to 80% yield. The products were easily converted to unnatural amino acids, aryl azo compounds and peptides as demonstrations of their wide potential applications.

Source: Chemical Science

DOI: 10.1039/d5sc05582b

Authors: Yu-Meng Ye, Zhi Li

Institution: ShanghaiTech University

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: Innovative Research Group Project of the National Natural Science Foundation of China, ShanghaiTech University

Awards: G1494773608, G5964250088