Work

Delta-opioid receptor–mediated neural protection and regeneration

Year: 2025

Type: article

Abstract: The delta-opioid receptor was previously viewed as a mediator in pain regulation. Recent data shed light on its specific role in neural protection and regeneration. An up-regulation of delta-opioid receptor expression and/or activity protects neuronal cells/tissues against various injuries and promotes neural regeneration. This review focuses on these new findings and the underlying mechanisms. In particular, we summarize the following key points: (1) the role of delta-opioid receptor in neuroprotection across various models and conditions; (2) the mechanisms of delta-opioid receptor neuroprotection against acute injury; (3) the neuroprotective mechanisms of delta-opioid receptor during prolonged injury; (4) delta-opioid receptor protection against ischemic and degenerative brain diseases and the underlying mechanisms; and (5) the regulation of delta-opioid receptor in neural regeneration. This article aims to provide an overview of delta-opioid receptor-mediated neural protection and regeneration, as well as its potential in treating neurological diseases.

Source: Neural Regeneration Research

DOI: 10.4103/nrr.nrr-d-25-00293

Authors: Jiahui Li, Yuan Xu, Ziyu Chao, Leena Khiati, Ying Xia

Institutions: Fudan University, Shanghai Research Center for Acupuncture and Meridians, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Soochow University, The First People's Hospital of Changzhou

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500