The 2025 EQUAL Pneumocystis Score—an ECMM tool to measure QUALity in Pneumocystis pneumonia management
Year: 2025
Type: article
Abstract: Background Pneumocystis pneumonia (PCP) is an opportunistic fungal infection. Several guidelines have been published to support its clinical management. However, the complexity and breadth of these guidelines pose challenges for consistent implementation in routine clinical practice. Objectives To develop a scoring tool and quality indicator that facilitates clinical decision making and quantifies adherence to best-practice guidelines for PCP in patients with and without HIV. Methods Key recommendations for the diagnosis, treatment and follow-up of PCP were extracted from current guidelines of the European Council on Infections in Leukaemia (ECIL), the American Society of Transplantation Infectious Diseases Community of Practice (AST-IDCOP), and the IDSA guidelines. Each recommendation was assigned a point value ranging from −1 to 3, weighted according to the strength of recommendation and level of evidence. Results The proposed 2025 European Confederation of Medical Mycology (ECMM) QUALity (EQUAL) Pneumocystis Score consists of 24 items for patients with HIV and 22 for patients without HIV. For diagnosis, bronchoalveolar lavage and immunofluorescence assays received the highest scores due to their superior sensitivity and specificity for sampling and analysis. Trimethoprim/sulfamethoxazole is the treatment of choice and was awarded with the highest score. The addition of corticosteroids for patients with HIV and respiratory failure completes the treatment category. The score is completed with the patient follow-up. For HIV patients a maximum score of 31 and for non-HIV patients a maximum score of 27 is achievable. Conclusions The 2025 EQUAL Pneumocystis Score offers a concise, evidence-based tool for the optimal management of PCP. This can be useful in daily practice for a quick overview and may be used to measure guideline adherence in research settings. It has not yet been assessed whether higher EQUAL Pneumocystis Scores are associated with improved patient outcomes.
Source: JAC-Antimicrobial Resistance
Institutions: University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University Hospital Cologne, German Center for Infection Research, Centre Hospitalier Universitaire de Rennes, Inserm, École des Hautes Études en Santé Publique, Institut de Recherche en Santé, Environnement et Travail, Université de Rennes, Radboud University Nijmegen, Radboud University Medical Center, Canisius-Wilhelmina Ziekenhuis
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,609
Funders: Pfizer, AstraZeneca, Sanofi, Gilead Sciences, Medpace, Deutsches Zentrum für Infektionsforschung, HELIOS Kliniken, Cidara Therapeutics, Jazz Pharmaceuticals, Moderna, Deutsche Forschungsgemeinschaft, European Society of Clinical Microbiology and Infectious Diseases, Bundesministerium für Bildung und Forschung, Astellas Pharma, Shionogi, Ludwig-Maximilians-Universität München, Ipsen, Seqirus, Sanofi-Aventis Deutschland
OpenAlex ID: W4414614554