Interaction Study of Ambient PM2.5 Exposure and SVIL Polymorphism with Hypertension in Koreans
Year: 2025
Type: article
Study design: Observational Study
Abstract: Hypertension is defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg.The exact cause of hypertension has not been identified, but genetic factors and environmental factors, such as air pollution, interact to cause hypertension.Therefore, this study examined the relationship between PM 2.5 and genetic polymorphisms on hypertension using the Korea Genome and Epidemiology Study cohort.As a result, the incidence of hypertension increased according to the level of exposure to PM 2.5 .The odds ratio (OR) increased by 3.07 (P=5.408×10-14 , 95% confidence interval [CI]=2.29~4.11) in the highest exposure group (PM 2.5 ≥31.6 μg/m³) compared to the lowest exposure group (PM 2.5 <28 μg/m³).In addition, this study identified six single nucleotide polymorphisms (SNPs) that showed statistically significant relationships (P<0.001) between hypertensive patients (n=752) and controls (n=2,115).Among the SNPs, rs11007696 showed a high association with hypertension (P=6.231×10-6 , OR=0.73, 95% CI=0.64~0.84).The risk of hypertension increased further when genetic and environmental factors were combined (P=4.265×10-5 , OR=3.98, 95% CI=2.04~7.78).This suggests that exposure to PM 2.5 and SVIL polymorphisms are related to the development of hypertension in Koreans, which may provide a new guideline for managing the progression of hypertension.
Authors: Jeongyoun KIM, Dahyun HWANG
Institution: Hoseo University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4414616565
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