A Case-Control Study on Maternal Pregnancy and Perinatal Conditions and Childhood Attention-Deficit/Hyperactivity Disorder
Year: 2025
Type: book-chapter
Study design: Observational Study
Abstract: Objective: To investigate the associations between childhood attention deficit hyperactivity disorder (ADHD) risk and key perinatal factors: maternal tobacco and alcohol exposure during pregnancy, parity, gestational age/preterm status, and delivery mode, to provide evidence for ADHD prevention. Methods: A total of 75 children with ADHD from The First People’s Hospital of Chenzhou City between October 2024 and April 2025 were enrolled as the case group, while 125 children without ADHD from the same hospital served as controls. General demographic characteristics and maternal pregnancy/perinatal conditions were assessed through parent-reported questionnaires. Logistic regression was used to analyze the data. Results: The case group exhibited a 4.6-fold higher rate of prenatal tobacco exposure compared to controls (OR = 4.626, 95%CI:1.439–14.874). Conversely, the proportion of full-term infants in the case group was significantly lower than in the control group (OR = 0.260, 95% CI:0.084–0.809). Conclusion: Maternal prenatal tobacco exposure may be a risk factor for childhood ADHD, whereas full-term birth is a protective factor. Targeted preventive measures, including reducing prenatal tobacco exposure and preventing preterm birth, may help mitigate ADHD incidence.
DOI: 10.3233/faia250748
Authors: Tian Zeng, Yanshan Duan, Jiayi Yao, Yang Li, Xinyi Li, Xufei Liu, Feiping He, Bin Xie, Hongxia Yuan, Yu Liu
Institutions: Xiangnan University, Chenzhou First People's Hospital
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414616761