Work

Harnessing Phenonium Ions in Synthesis

Year: 2025

Type: article

Abstract: Whereas phenonium ions have been known for decades, their use in synthesis has been surprisingly scarce. This might be attributed to the difficulty in taming their formation and reactivity. However, by considering the physical‐organic properties of phenonium species, through careful design of substrates, or the use of defined reagents/promoter systems, several applications have emerged in recent years to overcome those challenges. This minireview encompasses key recent strategies to generate those highly reactive cationic intermediates in line with their physicochemical properties, with special emphasis on mechanistic aspects, regioselectivity, and functional group compatibility.

Source: Angewandte Chemie

DOI: 10.1002/ange.202516932

Authors: Robert J. Mayer, David Lebœuf

Institutions: Technical University of Munich, Centre National de la Recherche Scientifique, Université de Haute-Alsace, Laboratoire d'innovation moléculaire et applications, Université de Strasbourg

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funder: Agence Nationale de la Recherche