Work

Stereoselective Synthesis of Complex α‐Amino Acid Derivatives Using Boron and Palladium Chemistry

Year: 2025

Type: article

Abstract: Matteson homologation of boronic acid esters allows the highly stereoselective synthesis of complex allyl alcohols, which are valuable substrates for palladium‐catalyzed allylic alkylations. With highly reactive amino acid zinc enolates, trans ‐configured γ , δ ‐unsaturated amino acid derivatives are obtained as single regioisomer. Excellent 1,4‐chirality transfer from the allylic substrate into the stereogenic α ‐center of the amino acid is observed in all cases.

Source: Zeitschrift für anorganische und allgemeine Chemie

DOI: 10.1002/zaac.202500160

Authors: Ronja Priester, Uli Kazmaier

Institution: Saarland University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,960

OpenAlex ID: W4414617667

FWCI:

Cites: 56

Cited by:

Related to: