Scalp seborrheic dermatitis demonstrates a skewing of Th1 activation: a proteomic study in lesional skin
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Scalp seborrheic dermatitis (SSD) is a common, chronic inflammatory skin disease. Its pathogenesis and immunological features have been poorly studied. Objective: To elucidate the molecular profile of adult patients with SSD in lesional scalps. Methods: Using punch biopsies, we assessed 92 inflammatory biomarkers in the lesional scalps of SSD patients (n=16) and demographically matched healthy controls (HCs; n=12) via Olink high-throughput proteomics. Results: We identified 16 differentially expressed proteins (DEPs) between lesional scalps of patients with SSD and those of HCs. SSD lesional scalps demonstrated significantly greater expressions of proteins related to T-cell/lymphocyte activation, the cytokine storm signaling pathway and the CGAS-STING signaling pathway. Ingenuity pathway analysis (IPA) highlighted Th1 skewing. These data suggest that SSD is associated with Th1 skewing and the dysregulation of lipid metabolism. Conclusion: These analyses provide a rationale for novel treatment approaches for SSD patients, mainly those targeting Th1 pathways.
Source: Frontiers in Immunology
Authors: Ningning Shen, Wei Chen, Lihua Hu, Jia Huang, Qiang Dong
Language: English
Topic: Nail Diseases and Treatments
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4414618438