Work

From demyelination to neurodegeneration in multiple sclerosis: reassessing the role of visual evoked potential P100-N145 amplitudes: a missing piece of the puzzle?

Year: 2025

Type: article

Abstract: Background: Multiple sclerosis (MS) is a chronic demyelinating disease with a heterogeneous clinical course, making long-term disability prediction challenging. Visual evoked potentials (VEPs), particularly amplitude-based parameters, may serve as sensitive biomarkers of neurodegeneration and functional decline undetected by conventional clinical measures. Objective: To assess the relationship between longitudinal changes in P100-N145 amplitude and concurrent Expanded Disability Status Scale (EDSS) changes in relapsing-remitting MS (RRMS) and the relative utility of baseline and longitudinal VEP parameters in representing disability status. Methods: In this retrospective cohort study, 45 MS patients (90 eyes) with available VEP and EDSS data were followed for a median period of 48 months. The primary endpoints were (1) change in EDSS score over time and (2) EDSS progression, defined as any increase in EDSS score from baseline to follow-up. Generalized estimating equations (GEE) and logistic regression were used to investigate the relationships between the VEP parameters at baseline and follow-up and EDSS progression, accounting for inter-eye correlation; partial correlation analysis assessed amplitude-EDSS change associations, controlling for age. Results: > 0.05). Conclusion: Our results demonstrate that a reduction in P100-N145 amplitude over time is associated with worsening disability in RRMS. This suggests that the P100-N145 may be an underestimated marker of progressive functional deterioration in RRMS.

Source: Frontiers in Neurology

DOI: 10.3389/fneur.2025.1649998

Authors: Nurhan Kaya Tutar, Nilufer Kale

Institution: Bağcılar Eğitim ve Araştırma Hastanesi

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801