Optimizing Intraoperative Fluid Management: Evidence From a Three-arm Trial of Crystalloids and Colloids in Abdominal Surgery
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Optimal intraoperative fluid management remains debated,with crystalloids associated with tissue edema and colloids offering greater plasma expansion but raising safety concerns. This study compared Ringers lactate (RL) alone with RL supplemented by 6% hetastarch (HS-RL) or 6% tetrastarch (TS-RL) in patients undergoing major gastrointestinal surgery. Methods: In this randomized controlled trial,120 patients were allocated into three groups(RL, HS-RL, TS-RL; n=40 each). Perioperative fluid management was guided by central venous pressure.Baseline characteristics and surgical distribution were comparable. Outcomes included intraoperative fluid requirements, gastrointestinal recovery, ambulation, ICU and hospital stay, and postoperative complications. Conclusion: Supplementing RL with balanced colloids enhanced recovery without increasing renal risk or mortality. Judicious colloid use may be a safe and effective intraoperative strategy in gastrointestinal surgery.
Authors: Amit Sehgal, Abhishek Misra, Prashant Bhatia, Saurabh Wadhwa
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4414618997
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