L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling
Year: 2025
Type: article
Abstract: . In gestational obesity mice, LTA administration reduced weight gain, visceral/gonadal adiposity, metabolic markers (fasting glucose/insulin/cholesterol), gut barrier dysfunction (TNF-α, IL-6, IL-8, Claudin-2), and linked to FXR/FGF15 pathway alterations. Furthermore, LTA intervention suppressed MCP-1, IL-1β, F4/80 and hepatic lipid metabolism regulators (CD36, SREBP1c, SCD1, GLUT4, Cyp7a1, IRS-1), while also mitigating placental tissue junction zone abnormalities and pup weight. To sum up, LTA-mediated attenuation of adverse pregnancy outcomes associates with FXR/FGF15 pathway alterations, concomitant with restoration of metabolic homeostasis and inflammation suppression.
Authors: Le Huang, Hua Li, Weitao Yang, Lihui Huang, Qiuling Chen, Shengnan Li, Zhi Zou, Lijing Zhao, Zhihua Zeng
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1607223817, G3048218680
OpenAlex ID: W4414619149