Gender Difference in the Relationship between Albuminuria, Insulin Resistance, and Beta Cell Function in Non-diabetic Korean Adults
Year: 2025
Type: article
Abstract: This study examined the relationship between albuminuria and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-β) in non-diabetic Korean adults.This study included 4,895 adults aged 20 or older using the 2020 Korea National Health and Nutrition Examination Survey data.After adjusting for the related variables in men, the mean value of HOMA-IR in the albuminuria group (mean±standard error [M±SE], 2.86±0.18;95% confidence interval [CI], 2.50~3.22)was higher than in the normal group (M±SE, 2.35±0.04;95% CI, 2.26~2.43)(P=0.007),but there was no significant difference in women (P=0.036).After adjusting for the related variables in men, the mean value of HOMA-β in albuminuria group (M±SE, 130.36±9.12;95% CI, 112.47~148.24) was higher than in the normal group (M±SE, 100.57±2.21;95% CI, 96.24~104.90)(P=0.002),but there was no significant difference in women (P=0.588).Albuminuria was positively associated with increased insulin resistance and beta-cell function in Korean men without diabetes mellitus, but not in Korean women.
Authors: Mi Young GI, Mee Jeong PARK, Hyun YOON
Institution: WonKwang Health Science University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414619295
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