Work

Extramedullary Hematopoiesis of the Urinary Bladder Associated With Metastatic Prostatic Adenocarcinoma: A Case Report

Year: 2025

Type: article

Abstract: Extramedullary hematopoiesis (EMH) is the production of hematopoietic cells outside the bone marrow, which most commonly occurs in the liver, spleen, and lymph nodes. EMH involving the urinary bladder is exceptionally rare, with only a few cases reported. We present the first known case of bladder EMH secondary to bone marrow metastasis from prostatic adenocarcinoma. The patient presented with gross hematuria; cystoscopy revealed multiple bladder masses. Histopathological examination demonstrated erythroid and myeloid precursors, along with scattered megakaryocytes, confirmed by immunohistochemistry. Bladder EMH should be considered in the differential diagnosis of patients with solid tumors presenting with hematuria. Hemorrhagic cystitis can mimic this entity and lead to misdiagnosis. The awareness of this rare manifestation is essential for accurate diagnosis and appropriate management.

Source: Cureus

DOI: 10.7759/cureus.93516

Author: Jirawat Chuaykaew

Institution: Chonburi Hospital

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414619344