Role of Ultrafast Dynamic Contrast-Enhanced MRI in Breast Cancer Prognostication: Correlation Between Early Kinetic Parameters and Tumor Aggressiveness and Histopathologic Characteristics
Year: 2025
Type: article
Study design: Observational Study
Abstract: Purpose: To evaluate whether early kinetic parameters from ultrafast dynamic contrast-enhanced (DCE) MRI correlate with the histopathological and morphological features of tumors. Materials and Methods: We retrospectively included 101 women with breast cancer (103 lesions; 85 invasive and 18 in situ) who underwent preoperative ultrafast DCE-MRI using compressed sensing between January 2020 and July 2022. Two radiologists assessed early kinetic parameters, time to enhancement (TTE) and maximum slope (MS), from the time-intensity curves. These were compared with prognostic factors. Results: = 0.015 for MS) as independent predictors of shorter TTE and higher MS. Inter-reader agreement for TTE and MS measurements was excellent, with intraclass correlation coefficient values of 0.951 and 0.879, respectively. Conclusion: Early kinetic parameters from ultrafast DCE-MRI strongly correlated with certain clinicopathological prognostic factors of breast cancer.
Authors: Seo Yeon Choe, Keum Won Kim, Young Joong Kim, Jae Yeong Seo
Institutions: Konyang University, Konyang University Hospital
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414620363