Design and Characterization of Langmuir–Blodgett Films Incorporating Europium Complexes and Nucleoside Derivatives for Cancer Therapeutic Applications
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The design of multifunctional nanostructured materials with potential for both diagnostic and therapeutic use, the so-called theranostic platforms, is a promising strategy in cancer research. In this study, we report the fabrication and physicochemical characterization of Langmuir and Langmuir–Blodgett (LB) films composed of a triacylated uridine derivative (PNM2), previously described as a prodrug with anticancer potential, and the europium complex Eu(tta) 3 (H 2 O) 2, known for its luminescent and structural probe properties. Langmuir monolayers at the air–water interface exhibited high rigidity for PNM2, which was modulated upon incorporation of the europium complex. Surface pressure–area isotherms, surface potential data, and dilatational rheology confirmed a transition toward a more fluid-like yet stable film. PM-IRRAS and Brewster angle microscopy indicated uniform molecular organization and specific interactions between Eu 3 + and the carbonyl groups of PNM2. Upon transfer to solid substrates, LB films preserved this organization and exhibited strong photoluminescence, with emission spectra confirming efficient energy transfer via the antenna effect. Lifetime and quantum efficiency measurements revealed reduced water coordination and enhanced radiative decay. These results demonstrate that PNM2–Eu(tta) 3 (H 2 O) 2 films are structurally robust and optically responsive systems, offering a promising foundation for the development of biofunctional interfaces with potential theranostic applications, including cancer sensing and localized drug delivery.
Source: ACS Omega
Authors: Guilherme Coutinho Pereira, Kevin Figueiredo dos Santos, Jhon Fernando Berrío Escobar, Cristiano Giordani, Luciano Caseli, Celso Molina
Institutions: Universidade Federal de São Paulo, Universidad de Antioquia
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Awards: G3690646728, Development of nanostructured biosensors for the diagnosis of mental disorders biomarkers, Nanostructured interfaces for the investigation of bioactive substances in cell membrane models and for the construction of optoelectronic devices, G7398675375, G8177347814, Nanostructured materials based on alkylated nucleosides with anticancer properties incorporated in Langmuir and Langmuir-Blodgett films of lipids and luminescent probes
OpenAlex ID: W4414624817