Work

A therapeutic effect of Forodesine for CNS relapsed primary testicular T cell lymphoma after allogeneic transplantation

Year: 2025

Type: article

Abstract: Most primary testicular malignant lymphomas are derived from B-cell, with only a few cases of T-cell origin (primary testicular T cell lymphoma; PTTCL). In this report, we present a case of PTTCL who relapsed simultaneously in the central nervous system (CNS) and peripheral nerves, which was managed by allogeneic hematopoietic stem cell transplantation, but recurred again in the CNS. Treatment with the purine nucleotide phosphorylase inhibitor Forodesine achieved a therapeutic response. This finding suggests that Forodesine might be useful as a treatment option for CNS relapse in heavily treated T-cell lymphoma.

Source: Journal of the Japan Society of the Reticuloendothelial System

DOI: 10.3960/jslrt.25032

Authors: Hiroki Tsutsumi, Masahisa Kudo, Nobuo Maseki, Yasunobu Sekiguchi, Hirofumi Kobayashi

Institution: Saitama Cancer Center

Language: English

Topic: CNS Lymphoma Diagnosis and Treatment

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414625373

FWCI: 0.564

Cites: 19

Cited by: 1

Related to: