Work

Branched endovascular aneurysm repair complicated by disseminated intravascular coagulation while using tocilizumab

Year: 2025

Type: article

Abstract: Disseminated intravascular coagulation (DIC) has been reported as a complication following endovascular procedures. We present the case of a 69-year-old female with giant cell arteritis on tocilizumab therapy, who underwent a first-stage branched endovascular aneurysm repair for a Crawford type III thoracoabdominal aneurysm. Postoperatively, she developed DIC. After excluding other causes, we assumed endoleakage through the celiac branch combined with tocilizumab-induced hypofibrinogenemia as the primary cause. The second stage was expedited and tocilizumab discontinued. The DIC resolved within weeks. Although rare, hemostatic disbalances may occur after endovascular procedures. Tocilizumab might have facilitated the progression of DIC under these circumstances.

Source: Journal of Vascular Surgery Cases and Innovative Techniques

DOI: 10.1016/j.jvscit.2025.101936

Authors: Ella Lubberdink, Saskia E.M. Schols, Teba Alnima, Mark Dirven

Institutions: Radboud University Medical Center, Radboud University Nijmegen

Language: English

Topic: Aortic aneurysm repair treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,250