Get started
Work

The age- and sex-specific association between metabolic body composition and lung function: a cross-sectional study

Year: 2025
Type: article
Study design: Observational Study
Abstract: This study aimed to investigate the association between body composition and lung function. Metabolic body composition can independently predict the risk of poor lung function. Accordingly, this cross-sectional observational study included adults aged ≥18 years who attended annual health examinations at Xiamen Chang-Gung Hospital from 2013 to 2016. The study evaluated the association between lung function and metabolic body composition, after correcting for possible influencing factors. Males had a higher body mass index and waist-to-hip ratio and a higher prevalence of smoking and drinking histories. Additionally, men showed significantly higher mean arterial pressure, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, insulin, and homeostasis model assessment for insulin resistance values than those of women (all p < 0.001). The proportion of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) was also higher in men than in women (17.91% vs. 25.20% and 11.28% vs. 13.67%, respectively). However, female participants demonstrated better pulmonary function. The prevalence of restrictive lung disease (RLD) was substantially higher in men than in women. The study findings suggest that MUO, and to a lesser extent, metabolic obesity with normal weight (MONW), are independent risk factors for RLD. These results imply that MUO, and to a lesser extent, MONW, may serve as potential screening markers for preclinical RLD in annual health checkups.
DOI: 10.1507/endocrj.ej25-0218
Authors: Wen-Cheng Li, Yi-Hsuan Chen, Chia-Wei Lu, Yueh Lin, Ya-Hui Lee, Po-Ya Lin
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4414625514
FWCI:
Cites:
Cited by:
Related to: