Work

Understanding how structure shapes the architecture of homologous recombination

Year: 2025

Type: review

Abstract: Cells have evolved multiple pathways to preserve genome integrity, with homologous recombination (HR) playing a central role in the accurate repair of DNA-double strand breaks (DSBs) by using homologous templates. Several proteins are involved in HR, and their mutations have been associated with cancer initiation and progression. In this review, we present an overview of recent structural insights into the HR pathway, highlighting the pivotal role of structural approaches in elucidating this complex and finely regulated DNA repair machinery, with the aim of advancing understanding and informing future research in the field.

Source: Current Opinion in Structural Biology

DOI: 10.1016/j.sbi.2025.103164

Authors: Francesco Rinaldi, Stefania Girotto

Institution: Italian Institute of Technology

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,360

Funders: Fondazione AIRC per la ricerca sul cancro ETS, Associazione Italiana per la Ricerca sul Cancro, Ministero dell'Istruzione e del Merito