Development of Composition and Technology of Production Spray Based on Thick Extract From Inula Helenium L.
Year: 2025
Type: article
Abstract: Currently, various modified aerosol dosage forms, namely sprays, are becoming increasingly widespread. At the same time, the theoretical foundations for creating sprays in pharmaceutical technology have not been fully studied, and there is no clear answer to what a spray is a modification of aerosols or an independent dosage form. Sprays are of undoubted theoretical interest and have practical significance for pharmacy, medicine and cosmetology. The paper presents studies on the development of the composition and technology for obtaining an oral spray based on a thick extract of Inula helenium L. The spray, having the advantages of an aerosol package, is devoid of the disadvantages associated with the use of bottles under high pressure and the use of propellants as a carrier gas: relatively high cost, complexity, danger, the possibility of a cylinder explosion upon impact or storage at inappropriate temperature conditions, high flammability, fire and explosion hazard, inconvenience during transportation, the negative impact of freons on the ozone layer of the earth. The paper presents the results of selecting an extractant for obtaining a thick extract from the roots and rhizomes of Inula helenium L. The stages of developing a technology for obtaining a spray for the mouth and throat with an antibacterial effect based on a thick extract of Inula helenium L. are shown. Preclinical trials confirmed the antibacterial activity of the drug based on Inula helenium L. and its low toxicity. The methods and results of the study on the selection of groups of auxiliary components that provide optimal technological parameters for the spray are also presented. Physicochemical and technological properties of the obtained experimental samples of the spray were determined. Based on the results obtained, the most promising spray composition was selected for further research.
Source: Medicine and ecology
Institution: Karaganda Medical University
Language: English
Subfield: Drug Discovery
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4414628611