Year: 2025
Type: article
Abstract: Nerve conduits have demonstrated tremendous value in advancing nerve regeneration. The current research focuses on improving their neuro regenerative effects through structural optimization and functional enhancement. Here, an original responsive sponge nerve conduit (RSNC) comprising a three-dimensional (3D) foamed nanofiber scaffold integrated with polydopamine-coated black phosphorus (PDA@BP) hydrogel is developed to promote sciatic nerve regeneration. The aligned nanofibrous mats are prepared by electrospinning and then foamed by gas foaming technology to obtain 3D sponge nanofiber scaffolds, which are subsequently filled with conductive PDA@BP doped gelatin methacryloyl hydrogels. Leveraging the superior photothermal conversion efficiency of PDA@BP nanosheets, loaded nerve growth factors are released under near-infrared light exposure, thereby promoting cell differentiation. In vivo experiments notably prove that RSNCs excel in facilitating nerve regeneration and motor function recovery, highlighting their potential for clinical peripheral nerve repair and related biomedical applications.
Source: Journal of Nanobiotechnology
Authors: Sizhe Song, Ying Zhang, Dongyu Xu, Hui Zhang, Yu Wang, Huan Wang, Hao Wu, Renjie Chai
Institutions: Zhongda Hospital Southeast University, State Key Laboratory of Digital Medical Engineering, Southeast University, Beijing Institute of Technology, Aerospace Center Hospital, Wenzhou Institute, University of Chinese Academy of Sciences, Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University, Capital Medical University, Xuan Wu Hospital of the Capital Medical University, University of Electronic Science and Technology of China, Nantong University, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,790
Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, Department of Science and Technology of Sichuan Province, University of Chinese Academy of Sciences, Shenzhen Fundamental Research Program, National Key Research and Development Program of China, Basic and Applied Basic Research Foundation of Guangdong Province
OpenAlex ID: W4414629505