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Antisynthetase Syndrome With Classic Features and Anti‑PL‑7 Positivity: A Rare Immunologic Variant

Year: 2025

Type: article

Abstract: Antisynthetase syndrome (ASyS) is a rare and heterogeneous subtype of idiopathic inflammatory myopathies, characterized by the presence of autoantibodies against aminoacyl-tRNA synthetases. Among these, anti-PL-7 antibodies are infrequent and associated with variable clinical expression. We present the case of a 71-year-old woman who developed progressive proximal muscle weakness. Physical examination revealed a heliotrope rash and mechanic's hands. Laboratory tests showed markedly elevated creatine kinase levels, and chest computed tomography findings were consistent with interstitial lung disease. Serological testing confirmed the presence of anti-PL-7 antibodies, leading to the diagnosis of ASyS. This case highlights the diagnostic challenges of ASyS, particularly when rare autoantibodies such as anti-PL-7 are involved. Recognition of characteristic clinical features and serological findings is essential for timely diagnosis and appropriate management.

Source: Cureus

DOI: 10.7759/cureus.93503

Authors: Karen S Arrazola-Mendoza, Hugo E González-Chávez, Francisco De la Peña-Camacho, Emmanuel Reyes-Ferreira, Ulises Gomez-Alvarez

Institution: Institute for Social Security and Services for State Workers

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4414629841