Glucodensity functional profiles outperform traditional continuous glucose monitoring metrics
Year: 2025
Type: article
Abstract: Continuous glucose monitoring (CGM) data have revolutionized the management of type 1 diabetes, particularly when integrated with insulin pumps to mitigate clinical events such as hypoglycemia. Recently, there has been growing interest in utilizing CGM devices in clinical studies involving healthy and diabetic populations. However, efficiently exploiting the high temporal resolution of CGM profiles remains a significant challenge. Numerous indices-such as time-in-range metrics and glucose variability measures-have been proposed, but evidence suggests these metrics overlook critical aspects of dynamic glucose homeostasis. As an alternative method, this paper explores the clinical value of glucodensity metrics in capturing glucose dynamics-specifically the speed and acceleration of CGM time series-as new biomarkers for predicting long-term glucose outcomes. Our results demonstrate significant information gains, exceeding 20 % in terms of adjusted r-square, in forecasting glycosylated hemoglobin (HbA1c) and fasting plasma glucose (FPG) at five and eight years from baseline AEGIS data, compared to traditional non-CGM and CGM glucose biomarkers. These findings underscore the importance of incorporating more complex CGM functional metrics, such as the glucodensity approach, to fully capture continuous glucose fluctuations across different time-scales.
Source: Scientific Reports
Authors: Marcos Matabuena, Rahul Ghosal, Javier Enrique Aguilar, Ayya Keshet, Robert Wagner, Carmen Fernández Merino, Juan Sánchez Castro, Vadim Zipunnikov, Jukka-Pekka Onnela, Francisco Gude
Institutions: Harvard University, University of South Carolina, TU Dortmund University, Weizmann Institute of Science, Düsseldorf University Hospital, Deutsches Diabetes-Zentrum e.V., German Center for Diabetes Research, Heinrich Heine University Düsseldorf, Johns Hopkins University, Universidade de Santiago de Compostela, Complejo Hospitalario Universitario de Santiago, Servicio Gallego de Salud
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1075404386, G2620658983, Identificación y validación de biomarcadores para la detección de individuos con alto riesgo de desarrollar diabetes tipo 2 (AEGIS-BIO), G4045322892, G4494326864, Predicción del riesgo de diabetes tipo 2 a partir de los datos obtenidos mediante monitorización continua de la glucosa. Estudio poblacional de seguimiento, G5602316953, G5625590996, G7799207878
OpenAlex ID: W4414629971