Work

Is Candida albicans a promoting factor, rather than an inducing factor for oral cancer?

Year: 2025

Type: article

Abstract: Background: can directly induce the occurrence of oral cancer remains undetermined. Objective: in oral cancer. Methods: in oral carcinogenesis. Additionally, the somatic mutation landscape of chronic hyperplastic candidiasis (CHC)-a variant of oral candidiasis typically presenting with dysplasia-was characterized in biopsy tissues. Results: stimulation activated signaling pathways involved in inflammation and immune response, and promoted cancer formation in mice pre-treated with 4NQO. Conclusion: alone rarely induces carcinogenesis directly but can accelerate the malignant transformation of oral mucosa when combined with smoking.

Source: Journal of Oral Microbiology

DOI: 10.1080/20002297.2025.2564694

Authors: Xu Wang, Xinming Zhang, Shuangshuang Wu, Wenqing Zhang, Zhimin Yan

Institutions: Peking University, Peking University School and Hospital of Stomatology

Language: English

Topic: Oral Health Pathology and Treatment

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,428