Metastatic Mammary-Like Adenocarcinoma of the Vulva Responding to Cyclin-Dependent Kinase (CDK) Inhibitor: A Case Report and Literature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: Mammary-like adenocarcinoma originating in the vulva is extremely rare, even rarer when metastasized at diagnosis. It may arise from the primitive mammary ridge or mammary-like glands of the skin in the anogenital region. We report a case of a 47-year-old woman with diffuse bone metastasis and a vulvar lesion compatible with mammary-type adenocarcinoma, with no evidence of primary breast cancer. Systemic treatment followed protocols for hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer, using an aromatase inhibitor and ribociclib, resulting in a favorable clinical and metabolic response. Documenting this case contributes to the understanding and clinical management of this rare neoplasm.
Source: Cureus
DOI: 10.7759/cureus.93598
Authors: Filipa Pereira, Joana L Pimenta, Mariana Rei, Carla R Dias, Deolinda Pereira
Institution: IPO Porto
Language: English
Topic: Cancer and Skin Lesions
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4414639726